Publications & News
8/20/17 Kate Holloway received a Heroes of Chemistry award from the American Chemical Society to recognize the Merck team who invented ZEPATIER®, a significant new treatment for chronic Hepatitis C Virus infection. To see a short video about this discovery, click here. For more information on the Heroes of Chemistry award, click here.
1/2/17 Gfree Bio is happy to welcome Dr. M. Katharine Holloway. Kate brings significant expertise and experience in structure-based drug design after a highly successful career at Merck that included the invention of marketed protease inhibitors to treat HIV (Crixivan™) and HCV (Vanihep™ and Zepatier™). For more info, check out her bio.
7/11/16 Gfree Bio has been awarded an NIH Phase I STTR grant from NIGMS for a program titled: Polar samplng and optimization of protein-ligand cocrystal structures. Dr. Charles H. Reynolds, Founder of Gfree Bio, is Principal Investigator.
5/21/16 Gfree Bio to present at the CCG UGM in June.
4/1/16 Gfree Bio collaborator Nirvana Sciences has been awarded Phase II NIH SBIR grant.
11/25/15 Gfree Bio collaborator OptiKira awarded two NIH Grants.
9/23/15 The third Drug Discovery Reinvented Conference has been announced for February 21, 2017 in Cancun, Mexico.
5/13/15 Gfree Bio was recently profiled by the Kauffman Foundation.
5/13/15 The second Drug Discovery Reinvented Conference is scheduled for August of 2015. See the outstanding lineup of speakers.
5/1/15 European patent published for collaborative work with Madrigal Pharmaceuticals. D. Keith Hester, Robert J. Duguid, Martha Kelly, Anna Chasnoff, Gang Dong, Edwin L. Crow, Rebecca Taub, Charles H. Reynolds, Duk Soon Choi, Lianhe Shu, Ping Wang Method of synthesizing thyroid hormone analogs and polymorphs thereof, Madrigal Pharmaceuticals, Inc., F. Hoffmann-La Roche Ltd., PCT/US2013/060177, Mar 20, 2014.
1/26/15 NIH Phase II SBIR awarded to Phelix Therapeutics for development of pan-coronavirus inhibitors. Gfree Bio is collaborating with Phelix on this program.
6/15/14 NIH Phase II SBIR awarded to Vironika, LLC. Gfree Bio is a collaborator for this SBIR award.
Two recent publications from Gfree Bio among most read in ACS Med. Chem. Letters. These are: Protein-Ligand Cocrystal structures: We Can Do Better and Validity of Ligand Efficiency Metrics
5/1/2014 NIH Phase I STTR awarded to PPI Mimics. Charles H. Reynolds, Principal Investigator.
7/16/13 NIH STTR awarded FCCDC and Drexel College of Medicine. Collaboration with Gfree Bio.
Selected Publications by Charles H. Reynolds:
Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia